| 货号 | 4408/50 |
| 别名 | N-(2-Methoxy-2-oxoacetyl)glycine methyl ester |
| 供应商 | Tocris |
| 生物活性 | Prolyl 4-hydroxylase (P4H) inhibitor; inhibits hypoxia-inducible factor α(HIF-α) prolyl hydroxylase (HIF-PH). Increases levels of HIF-1α; promotes cell survival under hypoxic conditions. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 175.14 |
| 分子式 | C6H9NO5 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Barnuczet al (2013) Prolyl-hydroxylase inhibition preserves endothelial cell function in a rat model of vascular ischemia reperfusion injury. J.Pharmacol.Exp.Ther. 345 25. PMID: 23388095. Ayrapetovet al (2011) Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One 6 e26064. PMID: 22016813. Lombet al (2009) Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2α to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2α has a role in NGF-promoted survival of sympathetic neurons. Mol.Pharmacol. 75 1198. PMID: 19204094. Jaakkolaet al (2001) Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292 468. PMID: 11292861. |