| 货号 | 14441-5mg |
| 描述 | Pseurotin A is a secondary metabolite produced by Aspergillus and other fungi.1 Its expression is induced in response to hypoxia. Pseurotin A is a secondary metabolite produced by Aspergillus and other fungi.1 Its expression is induced in response to hypoxia.2 Pseurotin A has been shown to inhibit IgE production by mouse B cells in culture (IC50 = 3.6 μM) and dose-dependently (0.4-25 μg/ml) stimulate neuritogenic activity in rat pheochromocytoma PC12 cells.3,4 It also demonstrates nematicidal activity at 300 μg/ml.5 |
| 别名 | NSC 348694; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maiya, S.,Grundmann, A.,Li, X., et al. Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus. ChemBioChem 8(14), 1736-1743 (2007). 2.Vödisch, M.,Scherlach, K.,Winkler, R., et al. Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. Journal of Proteome Research 10(5), 2508-2524 (2011). 3.Ishikawa, M.,Ninomiya, T.,Akabane, H., et al. Pseurotin A and its analogues as inhibitors of immunoglobulin E production. Bioorganic & Medicinal Chemistry Letters 19(5), 1457-1460 (2009). 4.Komagata, D.,Fujita, S.,Yamashita, N., et al. Novel neuritogenic activities of pseurotin A and penicillic acid. Journal of Antibiotics 49(9), 958-959 (1996). 5.Hayashi, A.,Fujioka, S.,Nukina, M., et al. Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatus. Bioscience, Biotechnology, and Biochemistry 71(7), 1697-1702 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 431.4 |
| 分子式 | C22H25NO8 |
| CAS号 | 58523-30-1 |
| 稳定性 | ≥ 1 year |
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