Muraglitazar
货号：
10007853-1mg 基本售价：
3920.0 元 规格：
1 mg
产品信息
概述| 货号 | 10007853-1mg |
| 描述 | Muraglitazar is a dual agonist of PPARα and PPARγ (EC50s = 320 and 110 nM in vitro).1 It improves diabetes and other metabolic abnormalities while preserving β-cell function in db/dbmice.2 However, prolonged use has been shown to be associated with an increase in congestive heart failure in human clinical trials.3 |
| 别名 | BMS-298585; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Devasthale, P.V.,Chen, S.,Jeon, Y., et al. Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor α/γ dual agonist with efficacious glucose and lipid-lowering activities. Journal of Medicinal Chemistry 48, 2248-2250 (2005).
2.Harrity, T.,Farrelly, D.,Tieman, A., et al. Muraglitazar, a novel dual (α/γ) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves β-cell function in db/db mice. Diabetes 55(1), 240-248 (2006).
3.Rosenson, R.S.,Wright, R.S.,Farkouh, M., et al. Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects. American Heart Journal 164(5), 672-680 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 516.5 |
| 分子式 | C29H28N2O7 |
| CAS号 | 331741-94-7 |
| 稳定性 | ≥ 2 years |
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