5-Hydroxymethylcytosine Polyclonal Antibody
货号：
18289-1ea 基本售价：
3906.0 元 规格：
1 ea
产品信息
概述| 货号 | 18289-1ea |
| 描述 | DNA methylation of cytosine to 5-methylcytosine (5-mC) is an epigenetic mark that is relatively common in both plants and mammals and plays a role in transcriptional and chromatin regulation. It is also known that the Tet family of enzymes can catalyze the oxidation of 5-mC to 5-hydroxymethylcytosine (5-hmC), which may be a step in the demethylation of 5-mC, as no DNA demethylases are known.1 In healthy cells, DNA methylation occurs at CpG sites, but CpG islands are generally not modified. However, tumor cells show an increase in CpG island methylation and a decrease in individual CpG sites.1 This ‘hypo-methylation’ can lead to aberrant activation of genes. Cayman’s 5-hmC Polyclonal Antibody recognizes 5-hmC modified DNA in ELISA and blotting experiments. |
| 别名 | 5-hmC; |
| 应用 | Dot-Blot and ELISA |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, Y.,Pastor, W.A.,Zepeda-Martínez, J.A., et al. The anti-CMS technique for genome-wide mapping of 5-hydroxymethylcytosine. Nature Protocols 7(10), 1897-1908 (2012).
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| 免疫原 | human 5-hmC conjugated to KLH |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 2 years |
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