Oltipraz
货号：
15118-1g 基本售价：
3878.0 元 规格：
1 g
产品信息
概述| 货号 | 15118-1g |
| 描述 | Oltipraz, originally identified as an antischistosomiasis agent, is a potent anticarcinogen in a variety of animal models of cancer at concentrations of ~200 mg/kg.1 It is an effective inducer of phase I and II detoxifying enzymes, including glutathione S-tranferases, UDP-glucuronosyltransferases, NAD(P)H:quinone oxidoreductase, microsomal epoxide hydrolase, and aflatoxin aldehyde reductase.1,2 Induction of these metabolic enzymes by oltipraz has been linked to the transcription factor nuclear factor E2-related factor 2 and its activation of the antioxidant response element.1 In mice, oltipraz at 150 mg/kg can also induce expression of CYP2B, a gene regulated by the constitutive androstane receptor, a transcription factor important in the detoxification of endobiotic and xenobiotic substances.3 |
| 别名 | NSC 347901;RP 35972; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kensler, T.W.,Qian, G.S.,Chen, J.G., et al. Translational strategies for cancer prevention in liver. Nature Reviews.Cancer 3(5), 321-329 (2003).
2.Iida, K.,Itoh, K.,Kumagai, Y., et al. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Research 64(18), 6424-6431 (2004).
3.Merrell, M.D.,Jackson, J.P.,Augustine, L.M., et al. The Nrf2 activator oltipraz also activates the constitutive androstane receptor. Drug Metabolism and Disposition 36(8), 1716-1721 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 226.3 |
| 分子式 | C8H6N2S3 |
| CAS号 | 64224-21-1 |
| 稳定性 | ≥ 2 years |
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