(±)4-Hydroxymephenytoin
货号：
16124-25mg 基本售价：
3864.0 元 规格：
25 mg
产品信息
概述| 货号 | 16124-25mg |
| 描述 | (±)4-Hydroxymephenytoin is a metabolite of (S)-mephenytoin (Item No. 11913), a substrate of the cytochrome P450 (CYP) isoform CYP2C19 with anticonvulsant activities.1,2 It has been used for developing ultra-performance LC tandem mass spectrometry assays for evaluating CYP probe drugs and their relevant metabolites in human urine or plasma samples.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shimada, T.,Misono, K.S. and Guengerich, F.P. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. The Journal of Biological Chemisty 261(2), 909-921 (1986).
2.Wong, P.T.H.,Tan, S.F. and Lee, H.S. N-demethylation of methyl and dimethyl derivatives of phenytoin and their anticonvulsant activities in mice. Japanese Journal of Pharmacology 48(4), 473-478 (1988).
3.Stewart, N.A.,Buch, S.C.,Conrads, T.P., et al. A UPLC-MS/MS assay of the "Pittsburgh cocktail": Six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution. Analyst 136(3), 605-612 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 234.3 |
| 分子式 | C12H14N2O3 |
| CAS号 | 61837-65-8 |
| 稳定性 | ≥ 2 years |
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