| 货号 | 13691-5mg |
| 描述 | Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM).1 In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 μM).1 Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures.1 Tubacin inhibition of HDAC6 has been used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Butler, K.V.,Kalin, J.,Brochier, C., et al. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin A. Journal of the American Chemical Society 132(31), 10842-10846 (2010). 2.Chen, S.,Owens, G.C.,Makarenkova, H., et al. HDAC6 regulates mitochondrial transport in hippocampal neurons. PLoS One 5(5), (2010). 3.Cole, P.A. Chemical probes for histone-modifying enzymes. Nature Chemical Biology 4(10), 590-597 (2008). 4.Xu, K.,Dai, X.L.,Huang, H.C., et al. Targeting HDACs: A promising therapy for Alzheimer’s disease. Oxid.Med.Cell Longev. 2011, (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 721.9 |
| 分子式 | C41H43N3O7S |
| CAS号 | 537049-40-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |