| 货号 | 1348/10 |
| 别名 | 2-(6-Chloro-3-pyridinyl)-9-azabicyc |
| 供应商 | Tocris |
| 生物活性 | Subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2,α3,α7 and α1β1δεrespectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 350.8 |
| 分子式 | C13H15ClN2.C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in water with gentle warming |
| CAS号 | 200432-86-6 |
| 参考文献 | Caoet al (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release. Neuropharmacology 48 72. PMID: 15617729. Sharpleset al (2000) UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomes. J.Neurosci. 20 2783. PMID: 10751429. Wrightet al (1997) Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett. 72867. |