货号 | 2337/10 |
别名 | 2,3,6,7-Tetrahydro-9,10-dimethoxy-3 |
供应商 | Tocris |
生物活性 | Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models. |
运输条件 | Blue Ice |
存放说明 | Ambient |
纯度 | >97 % |
计算分子量 | 441.95 |
分子式 | C24H27N3O3.HCl |
可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
CAS号 | 78416-81-6 |
参考文献 | Agarwalet al (1987) Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb.Res. 47 191. PMID: 2821650. Lalet al (1984) Trequinsin, a potent new antihypertensive vasodilator in the series of 2-(arylimino)-3-alkyl-9,10-dimethoxy-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-ones. J.Med.Chem. 27 1470. PMID: 6492077. Ruppert and Weithmann (1982) HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. Life Sci. 31 2037. PMID: 6294426. |