| 货号 | 2464/5 |
| 别名 | 2',3'-O-(2,4,6-Trinitrophenyl)adenosi |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective P2X receptor antagonist. Inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Displays 1000-fold selectivity over P2X2, P2X4 and P2X7. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 1123.04 |
| 分子式 | C16H13N8O19P3.C24H64N4 |
| 可溶性/溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
| CAS号 | 61368-63-6 |
| 参考文献 | Lewiset al (1998) 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (TNP-ATP) - a nanomolar affinity antagonist at rat mesenteric artery P2X receptor ion channels. Br.J.Pharmacol. 124 1463. PMID: 9723959. Thomaset al (1998) The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose channels. J.Physiol. 509.2411. Virginioet al (1998) Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3 and heteromeric P2X2/3 receptors. Mol.Pharmacol. 53 969. PMID: 9614197. |