| 货号 | 1402/10 |
| 别名 | 4-[5-(4-Fluorophenyl)-2-[4-(methyls |
| 供应商 | Tocris |
| 生物活性 | Water-soluble salt of SB 203580 (Cat. No. 1202). Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK3β and PKBα. Shown to inhibit interleukin-2-induced T cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 413.89 |
| 分子式 | C21H16FN3OS.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water with gentle warming |
| CAS号 | 152121-47-6 |
| 参考文献 | Davieset al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351. Borsch-Hauboldet al (1998) Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. J.Biol.Chem. 273 28766. PMID: 9786874. Saklatvalaet al (1996) Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen on a thromboxane analogue. J.Biol.Chem. 271 6586. PMID: 8636072. Cuendaet al (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364 229. PMID: 7750577. |