| 货号 | 1292/1 |
| 别名 | (3S,6R,7E,9R,10R,12R,14S,15E,17E,19 |
| 供应商 | Tocris |
| 生物活性 | Antifungal and immunosuppressant. Specific inhibitor of mTOR (mammalian target of Rapamycin). Complexes with FKBP-12 and binds mTOR inhibiting its activity. Inhibits interleukin-2-induced phosphorylation and activation of p70 S6 kinase. Induces autophagy in yeast and mammalian cell lines. Drives hPSC differentiation to mesendoderm and blood progenitor cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 914.18 |
| 分子式 | C51H79NO13 |
| 可溶性/溶解性 | Soluble to 20 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 53123-88-9 |
| 参考文献 | Nazarethet al (2016) A multi-lineage screen reveals mTORC1 inhibition enhances human pluripotent stem cell mesendoderm and blood progenitor production. Stem Cell Reports 6 679. PMID: 27132889. Fleminget al (2011) Chemical modulators of autophagy as biological probes and potential therapeutics. 7 9. PMID: 21164513. Kobayashiet al (2007) Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis. Cancer Sci. 98 726. PMID: 17425689. Huanget al (2003) Rapamycins: mechanism of action and cellular resistance. Cancer Biol.Ther. 2 221. PMID: 12878853. Kuoet al (1992) Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 358 70. PMID: 1614535. |