| 货号 | 2006/10 |
| 别名 | (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a, |
| 供应商 | Tocris |
| 生物活性 | Potent blocker of high-conductance Ca2+-activated K+(BKCa, KCa1.1) channels. Binds to the α-subunit of BKCa(Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 435.56 |
| 分子式 | C27H33NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 57186-25-1 |
| 参考文献 | Bilmenet al (2002) The mechanism of inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase by paxilline. Arch.Biochem.Biophys. 406 55. PMID: 12234490. Sanchez and McManus (1996) Paxilline inhibition of the alpha-subunit of the high-conductance calcium-activated potassium channel. Neuropharmacology 35 963. PMID: 8938726. Knauset al (1994) Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33 5819. PMID: 7514038. |