| 货号 | 2627/1 |
| 别名 | (5S)-(tert-Butoxycarbonylamino)-6-p |
| 供应商 | Tocris |
| 生物活性 | Potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Exhibits equal potency for inhibition of Aβ40 and Aβ42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 672.85 |
| 分子式 | C39H52N4O6 |
| 可溶性/溶解性 | Soluble to 15 mM in DMSO |
| CAS号 | 292632-98-5 |
| 参考文献 | Williamset al (2008) Regulation of CXCR4 by the Notch ligand delta-like 4 in endothelial cells. Cancer Res. 68 1889. PMID: 18339870. Williamset al (2006) Up-regulation of the Notch ligand delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 107 931. PMID: 16219802. Shearmanet al (2000) L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid-β-protein precursor γ-secretase activity. Biochemistry 39 8698. PMID: 10913280. |