| 货号 | 1774/1 |
| 别名 | P4 |
| 供应商 | Tocris |
| 生物活性 | Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors. Cell-permeable version also available (Cat. No. 1775). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1121.26 |
| 分子式 | C47H80N18O14 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 251634-21-6 |
| 序列号 | QVPSRPNRAP |
| 参考文献 | Nonget al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920. Kittleret al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117. Grabset al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966. |