| 货号 | 2372/10 |
| 别名 | 5-(3-Bromophenyl)-7-[6-(4-morpholin |
| 供应商 | Tocris |
| 生物活性 | Potent non-nucleoside adenosine kinase inhibitor (IC50 = 1.7 nM), selective over other sites of adenosine interaction (A1, A2A and A3 receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 536.26 |
| 分子式 | C22H19N6OBr.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 214697-26-4 |
| 参考文献 | Leeet al (2001) Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 44 2133. PMID: 11405650. Jarviset al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive effects in the mouse. J.Pharmacol.Exp.Ther. 295 1156. PMID: 11082453. Kowaluket al (2000) ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 295 1165. PMID: 11082454. |