MeBIO
货号：
19573-25mg 基本售价：
3850.0 元 规格：
25 mg
产品信息
概述| 货号 | 19573-25mg |
| 描述 | MeBIO is a control analog of the GSK3α/β inhibitor, BIO (Item No. 13123). It displays minimal activity against Cdk1/Cyclin B, GSK3α/β, and Cdk5/p25 (IC50s = 92.0, 44-100, and >100 μM, respectively).1,2 MeBIO has been identified as an aryl hydrocarbon receptor (AhR) agonist (EC50s = 20 and 93 nM for yeast and a hepatoma cell line, respectively) that causes AhR to translocate to the nucleus.3 |
| 别名 | Me6BIO;1-Methyl-6-bromo-indirubin-3’-oxime; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Polychronopoulos, P.,Magiatis, P.,Skaltsounis, A.L., et al. Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. Journal of Medicinal Chemistry 47, 935-946 (2004).
2.Meijer, L.,Skaltsounis, A.L.,Magiatis, P., et al. GSK-3-selective inhibitors derived from tyrian purple indirubins. Chemistry & Biology 10, 1255-1266 (2003).
3.Knockaert, M.,Blondel, M.,Bach, S., et al. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23(25), 4400-4412 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 370.2 |
| 分子式 | C17H12BrN3O2 |
| CAS号 | 667463-95-8 |
| 稳定性 | ≥ 2 years |
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