| 货号 | 15583-5mg |
| 描述 | Elaiophylin is a macrodiolide antibiotic that can be isolated from various strains of Streptomyces.1,2 It displays in vitro anti-protozoal activity against both PlasmodiumandTrypanosoma(IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 = 870 ng/ml).3 Elaiophylin alone has no activity against Candida, although it enhances the anti-fungal activity of rapamycin (Item No. 13346).2 Elaiophylin also forms stable, long-lasting ion channels in bilayer membranes that are selective for cations.4 |
| 别名 | Azalomycin-B;Gopalamicin;Salbomycin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fiedler, H.P.,Wörner, W.,Zähner, H., et al. Metabolic products of microorganisms. 200 Isolation and characterization of niphithricins A, B, and elaiophylin, antibiotics produced by Streptomyces violaceoniger. J.Antibiot.(Tokyo) 34(9), 1107-1118 (1981). 2.Fang, A.,Wong, G.K. and Demain, A.L. Enhancement of the antifungal activity of rapamycin by the coproduced elaiophylin and nigericin. J.Antibiot.(Tokyo) 53(2), 158-162 (2000). 3.Otoguro, K.,Iwatsuki, M.,Ishiyama, A., et al. In vitro and in vivo antiprotozoal activities of bispolides and their derivatives. J.Antibiot.(Tokyo) 63(5), 275-277 (2010). 4.Grigoriev, P.A.,Schlegel, R. and Gräfe, U. Cation selective ion channels formed by macrodiolide antibiotic elaiophylin in lipid bilayer membranes. Bioelectrochemistry 54(1), 11-15 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1025.3 |
| 分子式 | C54H88O18 |
| CAS号 | 37318-06-2 |
| 稳定性 | ≥ 1 year |
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