| 货号 | 3205/100U |
| 别名 | Conotoxin Vc1.1 |
| 供应商 | Tocris |
| 生物活性 | Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC50 values are 19, 140, 980, 4200 and 7300 nM for α9α10,α6/α3β2β3,α6/α3β4,α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1806.98 |
| 分子式 | C71H103N23O2 |
| 序列号 | GCCSDPRCNYDHPEIC (Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16) |
| 参考文献 | Halaiet al (2009) Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor J.Biol.Chem. 284 20275. PMID: 19447885. Nevinet al (2007) Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins? Mol.Pharmacol 72 1406. PMID: 17804600. Vincleret al (2006) Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors. Proc.Nat.Acad.Sci.USA 10317880. Sandallet al (2003) A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo. Biochemistry 42 6904. PMID: 12779345. |