| 货号 | 2433/10 |
| 别名 | (6aR,10aR)-3-(1,1-Dimethylheptyl)-6 |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective CB2 receptor agonist (Ki values are 6.4 and 1043 nM for CB2 and CB1 receptors respectively). Potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 8.1 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 384.59 |
| 分子式 | C26H40O2 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Huffman (2000) The search for selective ligands for the CB2 receptor. Curr.Pharmaceut.Des. 61323. Huffmanet al (1999) 3-(1',1'-dimethylbutyl)-1-deoxy-D8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg.Med.Chem. 7 2905. PMID: 10658595. Rosset al (1999) Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br.J.Pharmacol. 126 665. PMID: 10188977. |