| 货号 | 4365/10 |
| 别名 | 4-[(4-Fluorophenyl)methoxy]-1-[4-[2 |
| 供应商 | Tocris |
| 生物活性 | Potent, selective melanin-concentrating hormone receptor 1 (MCH1R) antagonist (IC50= 5.6 nM in hMCH1R-expressing CHO cells). Displays selectivity for MCH1R over MCH2R (IC50 = >10μM). Decreases body weight in a mouse model of diet-induced obesity. Brain penetrant; orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 408.47 |
| 分子式 | C24H25FN2O3< |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. HCl and to 50 mM in DMSO |
| 参考文献 | Hagaet al (2011) Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists. Bioorg.Med.Chem. 19 883. PMID: 21190859. Itoet al (2009) Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice. Eur.J.Pharmacol. 624 77. PMID: 19836369. |