| 货号 | 5524/1 |
| 别名 | 8-[(4-Chlorophenyl)thio]-guanosine- |
| 供应商 | Tocris |
| 生物活性 | PKG inhibitor (Ki values are 0.45, 0.5 and 0.7 μM for PKGIβ, PKGIα and PKGII respectively). Exhibits selectivity for PKG over PKA and Epac-1. Reduces LTP in hippocampal slices in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 525.86 |
| 分子式 | C16H14ClN5NaO |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Kimet al (2015) Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc.Natl.Acad.Sci.U.S.A. 112 3122. PMID: 25713349. Poppeet al (2008) Cyclic nucleotide analogs as probes of signaling pathways. Nat.Methods 5 277. PMID: 18376388. Gammet al (1995) The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. J.Biol.Chem. 270 27380. PMID: 7593002. |