| 货号 | 5094/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory function in hemorrhage-shocked rats. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1180.41 |
| 分子式 | C59H85N15O11 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in 25% ethanol / water |
| 序列号 | XDPFRWKPV (Modifications: X-1 = Ac-Nle, Phe-4 = D-Phe, Val-9 = C-terminal amide, Asp-2, Lys-7, Cyclized) |
| 参考文献 | Giulianiet al (2007) Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br.J.Pharmacol. 150 595. PMID: 17245369. Griecoet al (2003) Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. J.Pept.Res. 62 199. PMID: 14531843. |