| 货号 | 4803/10 |
| 别名 | (T-4)-[(1E,6E)-1,7-Bis[4-(dimethyla |
| 供应商 | Tocris |
| 生物活性 | Near-infrared probe that binds to Aβ40 aggregates (Kd = 38 nM) and elicits an emission blue shift. Shown to bind to plaques in APP-PS1 transgenic mice, in vitro. Detects senile plaques in 19-month-old Tg2576 mice in vivo. Penetrates the blood-brain barrier. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 410.26 |
| 分子式 | C23H25BF2N2< |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO with gentle warming |
| 参考文献 | Ranet al (2011) Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 6 e19362. PMID: 21559413. Ranet al (2009) Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J.Am.Chem.Soc. 131 15257. PMID: 19807070. |