| 货号 | 2512/10 |
| 别名 | α-[(S)-(Phosphonomethyl)amino]-3-dib |
| 供应商 | Tocris |
| 生物活性 | Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 349.28 |
| 分子式 | C16H16NO6P |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH |
| CAS号 | 261619-50-5 |
| 参考文献 | Kwanet al (2002) Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor. Neuropharmacol.Neurotoxicol. 13197. De Lombaertet al (2000) Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J.Med.Chem. 43 488. PMID: 10669576. Trapaniet al (2000) Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J.Cardiovasc.Pharmacol. 36 (5 Suppl. 1) S40. PMID: 11078331. |