| 货号 | 2699/1 |
| 别名 | Gal(2-11)amide |
| 供应商 | Tocris |
| 生物活性 | Selective galanin GAL2 receptor agonist (IC50 values are 1.76 and 879 nM for GAL2 and GAL1 respectively). Also shows moderate affinity for GAL3 receptors (Ki values are 88 and 271 nM for GAL2 and GAL3 respectively). Antiepileptogenic agent; prevents full seizures and postkindling increases in hippocampal excitability. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1136.31 |
| 分子式 | C54H81N13O14 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 20% formic acid |
| CAS号 | 367518-31-8 |
| 序列号 | WTLNSAGYLL (Modifications: Leu-10 = C-terminal amide) |
| 参考文献 | Mazaratiet al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700. PMID: 16699066. Luet al (2005) Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides 39 165. PMID: 15944007. Liuet al (2001) Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors. Proc.Natl.Acad.Sci USA 989960. |