| 货号 | 9000414-100ug |
| 描述 | PtdIns-(3,4,5)-P3(1,2-dipalmitoyl)-d62 (sodium salt) contains 62 deuterium atoms at the 2, 2’, 3, 3’, 4, 4’, 5, 5’, 6, 6’, 7, 7’, 8, 8’, 9, 9’, 10, 10’, 11, 11’, 12, 12’, 13, 13’, 14, 14’, 15, 15’, 16, 16, and 16 positions of each fatty acyl chain. It is intended for use as an internal standard for the quantification of PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) by GC- or LC-mass spectrometry (MS). The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.1,2PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.3,4 Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see references 5and6. |
| 别名 | DPPI-3,4,5-P3-d62;Phosphatidylinositol-3,4,5-trisphosphate C-16-d62; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lapetina, E.G.,Billah, M.M., and Cuatrecasas, P. The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature 292, 367-369 (1981). 2.Majerus, P.W. Inositol phosphate biochemistry. Annual Reviews of Biochemistry 61, 225-250 (1992). 3.Tanaka, K.,Imajoh-Ohmi, S.,Sawada, T., et al. A target of phosphatidylinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains. European Journal of Biochemistry 245, 512-519 (1997). 4.Yang, X.,Rudolf, M.,Carew, M.A., et al. Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. The Journal of Biological Chemisty 274, 18973-18980 (1999). 5.Pike, L.J., and Casey, L. Localization and turnover of phosphatidylinositol 4,5-bisphosphate in caveolin-enriched membrane domains. The Journal of Biological Chemisty 271, 26453-26456 (1996). 6.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d62) |
| 计算分子量 | 1201.3 |
| 分子式 | C41H16D62O22P4 • 4Na |
| 稳定性 | ≥ 2 years |
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