| 货号 | 1675/10 |
| 别名 | 5,6-Dihydro-2,3-dimethoxy-6,6-dimet |
| 供应商 | Tocris |
| 生物活性 | Novel, selective inhibitor of interleukin-5 (IL-5) (IC50 = 0.45 - 1 mM). Inhibits IL-5-prolonged eosinophil survival and IL-5-induced tyrosine phosphorylation of JAK2 without inhibiting GM-CSF-mediated effects. Inhibits antigen-induced eosinophil and lymphocyte recruitment in rat airways in vivo, without affecting peripheral blood or bone marrow leukocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 359.43 |
| 分子式 | C22H21N3O2 |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 163769-88-8 |
| 参考文献 | Morokataet al (2005) Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol.Lett. 98 161. PMID: 15790522. Morokataet al (2004) Effect of a novel interleukin-5 receptor antagonist, YM-90709 (2,3-dimethoxy-6,6-dimethyl-5,6-dihydrobenzo[7,8]indolizino[2,3-b]quinoxaline), on antigen-induced airway inflammation in BN rats. Int.Immunopharmacol. 4 873. PMID: 15182727. Morokataet al (2002) Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int.Immunopharmacol. 2 1693. PMID: 12469943. |