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货号： bs-2794R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2794R
- 英文名称
- RGS5
- 中文名称
- G蛋白信号转导调节因子5抗体
- 别 名
- MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; Regulator of G Protein Signalling 5; RGS 5; RGS5_HUMAN.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Rabbit,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 22kDa
- 细胞定位
- 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse RGS5:81-181/181
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. RGS5 seems to be an important signalling regulator in the vascular system. Present data suggest that RGS5 may be involved in the regulation of capillary growth, angiogenesis, and in the pathophysiology of stroke.
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.
Similarity:
Contains 1 RGS domain.
SWISS:
O08850
Gene ID:
19737
Database links:Entrez Gene: 8490 Human
Entrez Gene: 19737 Mouse
Entrez Gene: 54294 Rat
Omim: 603276 Human
SwissProt: O15539 Human
SwissProt: O08850 Mouse
SwissProt: Q864Z2 Pig
SwissProt: P49800 Rat
Unigene: 24950 Human
Unigene: 20954 Mouse
Unigene: 1150 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RGS5是调控G-蛋白活性的信号蛋白（RGS）家族的一员，是肿瘤血管形成的一个重要调控因子.主要与G蛋白α亚基结合，发挥GTP酶激活蛋白（GAPs）作用，负性调节G蛋白信号传导途径。Rgs5在体内多个器官都有表达，主要表达于这些组织器官的血管周细胞。近期发现，Rgs5与血管的生成、发展及成熟有密切关系，影响全身各系统功能。同时在一些肿瘤组织和细胞中也有高表达，且与肿瘤血管的异常有关。Rgs5基因的缺失可以使得肿瘤血管正常化，并促进免疫治疗的效果，提示其可能成为抗肿瘤血管治疗的新靶点。另外RGS5也可能是一种肿瘤相关抗原．对肿瘤诊断及治疗有着积极的意义．
- 产品图片
Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (RGS5) Polyclonal Antibody, Unconjugated (bs-2794R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.