| 货号 | 18749-1mg |
| 描述 | SB 202190 (Item No. 10010399) and SB 203580 (Item No. 13067) are potent, selective inhibitors of the MAP kinases p38α and p38β.1,2 SB 202474 is a structural analog of SB 202190 and SB 203580 that is used as a negative control in studies of p38 inhibition.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jiang, Y.,Chen, C.,Li, Z., et al. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). The Journal of Biological Chemisty 271(30), 17920-17926 (1996). 2.Davies, S.P.,Reddy, H.,Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochemistry Journal 351, 95-105 (2000). 3.Lee, J.C.,Laydon, J.T.,McDonnell, P.C., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372(22), 739-746 (1994). 4.Sweeney, G.,Somwar, R.,Ramlal, T., et al. An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. The Journal of Biological Chemisty 274(15), 10071-10078 (1999). 5.Chang, A.Y.W. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. Journal of Biomedical Science 19, (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 279.3 |
| 分子式 | C17H17N3O |
| CAS号 | 172747-50-1 |
| 稳定性 | ≥ 2 years |
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