SB 218078
货号：
13335-1mg 基本售价：
1610.0 元 规格：
1 mg
产品信息
概述| 货号 | 13335-1mg |
| 描述 | SB 218078 is an inhibitor of checkpoint kinase 1 (Chk1) that blocks phosphorylation of cdc25 with an IC50 value of 15 nM.1 It less potently inhibits cdc2 and PKC (IC50s = 250 and 1,000 nM, respectively) and causes 85% inhibition of PKD1 at 1 µM.1,2 SB 218078 releases G2 cell cycle arrest induced by γ-irradiation or the topoisomerase I inhibitor topotecan (Item No. 14129).1 In this way, SB 218078 enhances the cytotoxicity of DNA-damaging compounds.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jackson, J.R.,Gilmartin, A.,Imburgia, G., et al. An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage. Cancer Research 60(3), 566-572 (2000).
2.Tandon, M.,Johnson, J.,Li, Z., et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One 8(9), e75601 (2013).
3.Kawabe, T. G2 checkpoint abrogators as anticancer drugs. Molecular Cancer Therapeutics 3(4), 513-519 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 393.4 |
| 分子式 | C24H15N3O3 |
| CAS号 | 135897-06-2 |
| 稳定性 | ≥ 2 years |
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