| 货号 | 2204/10 |
| 别名 | N-[2-(3,4-Dihydroxyphenyl)ethyl]oct |
| 供应商 | Tocris |
| 生物活性 | Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitroandin vivo; enhances effects on intracellular Ca2+(EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 419.64 |
| 分子式 | C26H45NO3 |
| 可溶性/溶解性 | Soluble to 5 mM in ethanol with gentle warming |
| CAS号 | 105955-10-0 |
| 参考文献 | De Petrocelliset al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251. PMID: 15289293. Chuet al(2003)N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633. PMID: 12569099. |