| 货号 | 3504/50 |
| 别名 | P,P'-[1-Hydroxy-2-(3-pyridonyl)ethyl |
| 供应商 | Tocris |
| 生物活性 | Orally active biphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC50 = 100 nM). Exhibits antiproliferative and proapoptotic activity in numerous tumor cell lines and inhibits osteoclast-mediated bone resorption in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 305.09 |
| 分子式 | C7H10NNaO7P2 |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| CAS号 | 115436-72-1 |
| 参考文献 | Fournieret al (2008) Lowering bone mineral affinity of bisphosphonates as a therapeutic stragey to optimize skeletal tumor growth inhibition in vivo. Cancer Res. 68 8945. PMID: 18974139. Stresinget al (2007) Bisphosphonates in cancer therapy. Cancer Letts. 257 16. PMID: 17697748. Coxonet al (2006) Recent advances in understanding the mechanism of action of bisphosphonates. Curr.Opin.Pharmacol. 6 307. PMID: 16650801. Dunfordet al (2001) Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J.Pharmacol.Exp.Ther. 296 235. PMID: 11160603. |