| 货号 | 4942/10 |
| 别名 | (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fl |
| 供应商 | Tocris |
| 生物活性 | Synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 440.5 |
| 分子式 | C25H23FNO4.0.5Ca |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Sakaet al (2006) Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 47 770. PMID: 16810078. Mukhtaret al (2005) Pitavastatin. Int.J.Clin.Pract. 59 239. PMID: 15854203. Aokiet al (1997) Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 47 904. PMID: 9296275. |