| 货号 | 4616/50 |
| 别名 | 4-(1-Hydroxy-1-methylethyl)-2-propy |
| 供应商 | Tocris |
| 生物活性 | Potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil (Cat. No. 4620). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 446.5 |
| 分子式 | C24H26N6O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Chuanget al (2012) Effects of olmesartan on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 11 66. PMID: 22694778. Ojimaet al (2011) In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 336 801. PMID: 21123673. Mogiet al (2007) Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan. Neuropharmacology 53 899. PMID: 18028965. |