| 货号 | 4405/1 |
| 别名 | 4-Methyl-3-[[1-methyl-6-(3-pyridiny |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of EphB4 kinase; exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Inhibits EphB4 autophosphorylation in transiently transfected HEK 293 cells. Also inhibits VEGF-induced angiogenesis in vivo; thought to inhibit EphB4 forward signaling. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 617.5 |
| 分子式 | C26H20F3N7 |
| 可溶性/溶解性 | Soluble to 40 mM in DMSO |
| 参考文献 | Wnuket al (2012) Podocyte EphB4 signaling helps recovery from glomerular injury. Kidney Int. 81 1212. PMID: 22398409. Martiny-Baronet al (2010) The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 13 259. PMID: 20803239. |