| 货号 | 4102/50 |
| 别名 | 6-(1,3-Dihydro-4-hydroxy-6-methoxy- |
| 供应商 | Tocris |
| 生物活性 | Immunosuppressant prodrug of mycophenolic acid (MPA) (Cat. No. 1505). Hydrolyzed by esterases to release MPA (a reversible inhibitor of inosine monophosphate dehydrogenase). Used to prevent organ rejection after transplantation. Displays inhibitory activity of lymphocyte functions. Inhibits type 1 collagen expression, enhances MMP-1 expression, and reduces α-smooth muscle actin gene expression. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 433.49 |
| 分子式 | C23H31NO7 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| 参考文献 | Rooset al (2007) In vitro evidence for a direct antifibrotic role of the immunosuppressive drug mycophenolate mofetil. J.Pharm.Exp.Ther. 321583. Allison and Eugui (1996) Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin.Transplant. 10 77. PMID: 8680053. |