| 货号 | 1885/1 |
| 别名 | Myosin Light Chain Kinase Inhibitor Peptide 18 |
| 供应商 | Tocris |
| 生物活性 | Selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1324.64 |
| 分子式 | C60H105N23O11 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 224579-74-2 |
| 序列号 | RKKYKYRRK (Modifications: Lys-9 = C-terminal amide) |
| 参考文献 | Zolotarevskyet al (2002) A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123 163. PMID: 12105845. Lukaset al (1999) Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 42 910. PMID: 10072688. |