货号 | 3358/5 |
别名 | N-Acetyl-L-leucine-L-leucine-L-norl |
供应商 | Tocris |
生物活性 | Calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro. Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
计算分子量 | 383.53 |
分子式 | C20H37N3O4 |
可溶性/溶解性 | Soluble to 50 mM in DMSO and to 25 mM in ethanol |
CAS号 | 110044-82-1 |
参考文献 | Perrinet al (2002) In vitro antioxidant properties of calpain inhibitors: leupeptin and calpain inhibitor-1. Cell Mol.Biol. 48OL267. Chatterjeeet al (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int. 59 2073. PMID: 11380809. Atencioet al (2000) Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines. Cell Growth Differ. 11 247. PMID: 10845425. Sherwoodet al(1993)In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proc.Natl.Acad.Sci.USA 903353. |