| 货号 | 0773/50 |
| 别名 | 3,5-Dimethyl-tricyclo[3.3.1.13,7]de |
| 供应商 | Tocris |
| 生物活性 | An antagonist at the NMDA receptor, binding to the ion channel site. Used in the treatment of Parkinsonism. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 215.77 |
| 分子式 | C12H21N.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 19982-08-2 |
| 参考文献 | Parsonset al (2007) Memantine: A NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse. Neuropharmacology 53 699. PMID: 17904591. Parsonset al (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data. Neuropharmacology 38 735. PMID: 10465680. Chenet al (1998) Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Neuroscience 86 1121. PMID: 9697119. Zajaczkowskiet al (1997) Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP. Neuropharmacology 36 961. PMID: 9257940. |