| 货号 | 1998/1 |
| 供应商 | Tocris |
| 生物活性 | Potent, metabolically stable neurotensin receptor agonist peptide (IC50 = 0.15 nM for inhibition of [125I]-NT binding to neonatal mouse brain; EC50 = 1.9 nM for contraction of guinea pig ileum). Produces long-lasting hypothermic, neuroprotective and analgesic effects in mice following central administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 746.96 |
| 分子式 | C38H66N8O7 |
| 可溶性/溶解性 | Soluble to 0.80 mg/ml in water |
| CAS号 | 139026-66-7 |
| 序列号 | KKPYIL (Modifications: Lys-1 - Lys-2 peptide bond replace with Ψ(CH2-NH)) |
| 参考文献 | Torupet al (2003) Neuroprotective effect of the neurotensin analogue JMV-449 in a mouse model of permanent middle cerebral ischaemia. Neurosci.Lett. 351 173. PMID: 14623134. Dubucet al (1992) JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur.J.Pharmacol. 219 327. PMID: 1425958. Lugrinet al (1991) Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur.J.Pharmacol. 205 191. PMID: 1812009. |