| 货号 | 3103/1 |
| 别名 | 1,1'-[(1S,2R)-1-[(2S,4R,9R,11S,12S)- |
| 供应商 | Tocris |
| 生物活性 | Mycotoxin produced by Fusarium moniliforme. Potently inhibits sphingosine N-acyltransferase (ceramide synthase), causing an accumulation of sphingoid bases (IC50 ~ 75 nM). Also inhibits protein phosphatases; IC50 values are 80, 300, 400, 500 and 3000 μM for PP5, PP2Cα, PP2A, PP1γ2 and PP2B respectively. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 721.83 |
| 分子式 | C34H59NO15 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 116355-83-0 |
| 参考文献 | Blazquezet al (2008) Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. Cancer Res. 68 1945. PMID: 18339876. Fukudaet al (1996) Inhibition of protein serine/threonine phosphatases by Fumonisin B1, a mycotoxin. Biochem.Biophys.Res.Comms. 220160. Merrillet al (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J.Biol.Chem. 268 27299. PMID: 8262970. |