| 货号 | 2626/50 |
| 别名 | cis-Diammine(1,1-cyclobutanedicarbo |
| 供应商 | Tocris |
| 生物活性 | Antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Enhances radiation-induced single-strand DNA breakage and displays lower nephrotoxicity than analog cisplatin (Cat. No. 2251). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 371.25 |
| 分子式 | C6H12N2O4Pt |
| 可溶性/溶解性 | Soluble to 25 mM in water |
| CAS号 | 41575-94-4 |
| 参考文献 | Thomaset al (2006) High accumulation of platinum-DNA adducts in strial marginal cells of the cochlea is an early event in cisplatin but not carboplatin ototoxicity. Mol.Pharmacol. 70 23. PMID: 16569706. Natarajanet al (1999) Increased DNA-binding activity of cis-1,1-cyclobutanedicarboxylatodiammineplatinum (II) (carboplatin) in the presence of nucleophiles and human breast cancer MCF-7 cell cytoplasmic extracts: activation theory revisited. Biochem.Pharmacol. 58 1625. PMID: 10535754. Yanget al (1995) Carboplatin enhances the production and persistence of radiation-induced DNA single-strand breaks. Radiation Res. 143302. |