| 货号 | 3735/1 |
| 别名 | 4,5-Dihydro-2-[4-(4-methyl-1H-imida |
| 供应商 | Tocris |
| 生物活性 | PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively). Displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro; reduces myocardial infarct size in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 335.4 |
| 分子式 | C19H21N5O |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Sunderlandet al (2011) 5-Benzamidoisoquinolin-1-ones and 5-(omega-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2). J.Med.Chem. 54 2049. PMID: 21417348. Eltzeet al (2008) Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol.Pharmacol. 74 1587. PMID: 18809672. |