BIBU 1361 dihydrochloride (1 MG)
货号：
2417/1 基本售价：
1566.5 元 规格：
1 mg
产品信息
概述| 货号 | 2417/1 |
| 别名 | N-(3-Chloro-4-fluorophenyl)-6-[4-[(diethylamino)methyl]-1-piperidinyl]-pyrimido[5,4-d]pyrimidin-4-amine dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). Displays ~ 100-fold lower potency against ErbB2 (IC50 = 290 nM) and is selective over a range of other related tyrosine kinases (IC50 > 10 μM). Blocks downstream EGFR signaling events such as MAPKK/MAPK activation. Oral administration inhibits growth of established human xenografts in athymic mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 516.87 |
| 分子式 | C22H27ClFN7.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 25 mM in DMSO |
| CAS号 | 793726-84-8 |
| 参考文献 | Solcaet al (2004) Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives. J.Pharmacol.Exp.Ther. 311 502. PMID: 15199094. |
