| 货号 | 3979/50 |
| 别名 | N,N''-Bis(2-ethylhexyl)-3,12-diimino- |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μMin vitro). Stimulates increased insulin secretion by β-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells. Also preserves functional hematopoietic stem cells ex vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 581.71 |
| 分子式 | C26H56N10.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 1715-30-6 |
| 参考文献 | Liuet al (2015) Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism. Blood 125 1562. PMID: 25593337. Doughty-Shentonet al (2010) Pharmacological targeting of the mitochondrial phosphatase PTPMT1. J.Pharmacol.Exp.Ther. 333 584. PMID: 20167843. Yipet al (2006) Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent. Mol.Cancer Ther. 5 2234. PMID: 16985057. |