| 货号 | 3977/50 |
| 别名 | 3-Methyl-3H-purin-6-amine; 3-MA |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 149.15 |
| 分子式 | C6H7N5 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| CAS号 | 5142-23-4 |
| 参考文献 | Canuet al (2005) Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J.Neurochem. 92 1228. PMID: 15715672. Blommaartet al (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur.J.Biochem. 243 240. PMID: 9030745. Seglen and Gordon (1982) 3-methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc.Natl.Acad.Sci. USA 791889. |