| 货号 | 17082-500ug |
| 描述 | Apamin is an 18 amino acid peptide toxin found in bee venom. It is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels that is more effective at SK2 than SK1 and SK3 (IC50 values are 0.06-0.4, 1-12, and 1-13 nM, respectively).1,2 It is ineffective against SK4 at 1 µM.2 Apamin is used to elucidate the roles of these channels in cells and tissues expressing SK channels, including neurons, vascular endothelium, bladder smooth muscle, and certain types of cancer cells.3,4,5,6 |
| 别名 | Ro 23-6721; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maylie, J.,Bond, C.T.,Herson, P.S., et al. Small conductance Ca2+-activated K+ channels and calmodulin. Journal of Physiology 554(Pt 2), 255-261 (2004). 2.Wulff, H., and Köhler, R. Endothelial small-conductance and intermediate-conductance KCa channels: An update on their pharmacology and usefulness as cardiovascular targets. Journal of Cardiovascular Pharmacology 61(2), 102-112 (2013). 3.Triggle, C.R.,Hollenberg, M.,Anderson, T.J., et al. The endothelium in health and disease- A target for therapeutic intervention. Journal of Smooth Muscle Research 39(6), 249-267 (2003). 4.Pedarzani, P., and Stocker, M. Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain. Cellular and Molecular Life Sciences 65(20), 3196-3217 (2008). 5.Alvarez-Fischer, D.,Noelker, C.,Vulinovic, F., et al. Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model. PLoS One 8(4), 1-8 (2013). 6.Yu, C.C.,Ai, T.,Weiss, J.N., et al. Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents. PLoS One 9(5), 1-8 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 2027.3 |
| 分子式 | C79H131N31O24S4 |
| CAS号 | 24345-16-2 |
| 稳定性 | ≥ 1 year |
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