| 货号 | 19357-50mg |
| 描述 | Pyridoxal isonicotinoyl hydrazine is a lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and in vivo in rats and mice.1,2 Because iron is a crucial component of metabolic pathways involved in DNA synthesis, cancerous cells have a high iron requirement due to rapid rates of proliferation. While pyridoxal isonicotinoyl hydrazine exhibits low anticancer activity, its analogs demonstrate antiproliferative effects in a range of tumor cells.3,4,5 |
| 别名 | NSC 77674;PIH; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ponka, P.,Borova, J.,Neuwirt, J., et al. Mobilization of iron from reticulocytes. Identification of pyridoxal isonicotinoyl hydrazone as a new iron chelating agent. FEBS Letters 97(2), 317-321 (1979). 2.Richardson, D.R., and Ponka, P. Pyridoxal isonicotinoyl hydrazone and its analogs: Potential orally effective iron-chelating agents for the treatment of iron overload disease. Journal of Laboratory and Clinical Medicine 131(4), 306-315 (1998). 3.Merlot, A.M.,Pantarat, N.,Lovejoy, D.B., et al. Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer. Molecular Pharmacology 78(4), 675-684 (2010). 4.Richardson, D.R. Cytotoxic analogs of the iron(III) chelator pyridoxal isonicotinoyl hydrazone: Effects of complexation with copper(II), gallium(III), and iron (III) on their antiproliferative activities. Antimicrobial Agents and Chemotherapy 41(9), 2061-2063 (1997). 5.Gao, J., and Richardson, D.R. The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression. Blood 98(3), 842-850 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 286.3 |
| 分子式 | C14H14N4O3 |
| CAS号 | 737-86-0 |
| 稳定性 | ≥ 2 years |
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