| 货号 | 15590-1mg |
| 描述 | The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Item No. 13524), apelin-17, and apelin-13 (Item No. 13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.1,2 (Glp1)-Apelin-13 is a pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid. Like apelin-13, this compound is a potent APJ receptor agonist (EC50 = 0.30 nM).1 (Glp1)-Apelin-13 is the major apelin isoform in the plasma of healthy human subjects.3 It can have vasoconstrictor and antipyretic effects in vitroandin vivo.4,5,6 |
| 别名 | (pGlu1)Apelin-13;Pyr-Apelin-13;(Pyr1)Apelin-13; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tatemoto, K.,Hosoya, M.,Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998). 2.Lee, D.K.,Cheng, R.,Nguyen, T., et al. Characterization of apelin, the ligand for the APJ receptor. Journal of Neurochemistry 74, 34-41 (2000). 3.Zhen, E.Y.,Higgs, R.E. and Gutierrez, J.A. Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma. Analytical Biochemistry 442(1), 1-9 (2013). 4.Katugampola, S.D.,Maguire, J.J.,Matthewson, S.R., et al. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. British Journal of Pharmacology 132(6), 1255-1260 (2001). 5.Kagiyama, S.,Fukuhara, M.,Matsumura, K., et al. Central and peripheral cardiovascular actions of apelin in conscious rats. Regulatory Peptides 125(1-3), 55-59 (2005). 6.Hatzelmann, T.,Harden, L.M.,Roth, J., et al. Antipyretic effect of central [Pyr1]apelin13 on LPS-induced fever in the rat. Regulatory Peptides 184, 6-13 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1533.8 |
| 分子式 | C69H108N22O16S |
| CAS号 | 217082-60-5 |
| 稳定性 | ≥ 1 year |
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